A Personalized Prehabilitation Intervention In Elective Joint Replacement Surgery
Paused · Not applicable
Conditions studied: Arthropathy of Knee Joint, Arthropathy of Hip Joint
In brief
The mission is to develop novel interventions to improve cognitive function, and thereby reducing delirium in hospitalized patients to improve perioperative outcomes. Delirium affects up to 42% of hospitalized patients and disproportionately increases morbidity and mortality in older adults, especially after surgical procedures. Current approaches prevent only 30-40% of delirium cases. The goal is to use prehabilitation (an individualized exercise regimen performed in the 2-4 weeks prior to admission) to improve peri-operative cognitive status, mobility and recovery. Based on preliminary data, the investigators propose to deeply phenotype patients, meaning to study the patient, the disease and surgery in a very detailed fashion, with elective knee or hip replacement surgery and use a personalized prehabilitation intervention compared to standard pre-operative care. To facilitate data collection over the course of the study, the investigators use wearable devices and mobile phone applications.
Key facts
- Study ID
- NCT03601728
- Run by
- University of Pennsylvania
- People needed
- 28
- Starts
- 2019-10-01
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2026-05-29
Who can join
Age: 55 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults scheduled for elective arthroplasty;
- ≥55 years of age;
- Capable of giving informed consent;
- Willing to comply either to undergo prehabilitation (cases) or standard preoperative care (control);
- Own a smartphone.
You may not qualify if…
- Patients with bilateral or revision surgeries;
- Diagnosis of pre-existing dementia;
- Test result of <20 in the MoCA indicating moderate to severe dementia;
- Diagnosis of acute stroke;
- Diagnosis of neurologic injury;
- Current alcohol (more than 2 drinks a day with last drink within the past 3 days) or substance abuse (positive urine dip test for illicit drugs) history at risk of postoperative withdrawal;
- Active diagnosis of alcohol or substance abuse;
- Recent travel across more than two (2) time zones (within the past month);
- Planned travel across more than two (2) time zones during the planned study activities;
- Subjects, who have received an experimental drug, used an experimental medical device within 30 days prior to screening, or who gave a blood donation of ≥ one pint within 8 weeks prior to screening;
- Subjects without access to WiFi in their or close to home or at work.
Where it is running
- University of Pennsylvania School of Medicine — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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