Examining the Relationship Between Acute Meal Intake and Inflammation in Children

Completed · Not applicable

Conditions studied: Obesity, Inflammation

In brief

Recent evidence has shown that obese and overweight children exhibit states of chronic inflammation. In obese adults, a high carbohydrate meal induces an inflammatory response; however, the effects of a high carbohydrate meal on biomarkers of inflammation has not previously been examined in children. The purpose of this research project is to characterize the inflammatory response to a high carbohydrate versus a low carbohydrate meal in healthy weight, overweight, and obese children (age 7-17 years). After completing informed consent/assent, a Dual-energy X-ray Absorptiometry (DXA) scan, and baseline blood draw on experimental day 1, children will then return to the lab two times to ingest either a high or low carbohydrate beverage followed by post-meal blood collection for a total of 3 blood draws. Biomarkers of inflammation will be analyzed by flow cytometry and enzyme-linked immunosorbent assay (ELISA). Participants will be recruited through various studies through the Neurocognitive Kinesiology Lab/Body Composition and Nutritional Neuroscience Labs as well as through the local Champaign-Urbana community. Data from this project will provide a better understanding of the inflammatory response to different meals in healthy weight, overweight, and obese children.

Key facts

Study ID

NCT03597542

Run by

University of Illinois at Urbana-Champaign

People needed

36

Starts

2017-08-29

Expected to finish

2018-02-02

Last updated by the study team

2018-07-31

Who can join

Age: 7 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between the ages of 7-17

You may not qualify if…

• Younger than 7 years and older than 17 years
• Presence of allergies to eggs and/or sugar substitutes
• Presence of heart or respiratory disease
• Presence of uncontrolled hypertension, diabetes
• Use of anti-inflammatory medications
• Presence of cancer or metabolic disease

Where it is running

• University of Illinois at Urbana-Champaign — Urbana, Illinois, United States

Full record on ClinicalTrials.gov

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