Prospective Study for Symptomatic Relief of ET With Cala Therapy

Completed · Not applicable

Conditions studied: Essential Tremor

In brief

Prospective, multi-center, single-arm, non-significant risk study designed to evaluate the Cala TWO device. Subjects will be screened for eligibility and fitted with a Cala TWO device. Subjects will wear the device at home for a period of 3 months, during which they will be asked to stimulate their dominant hand twice a day. The stimulation amplitude will be based on each subject's stimulation threshold. Subjects will have in clinic assessments at enrollment, month 1 and 3.

Key facts

Study ID

NCT03597100

Run by

Cala Health, Inc.

People needed

263

Starts

2018-12-14

Expected to finish

2019-05-29

Last updated by the study team

2023-10-12

Who can join

Age: 22 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must be ≥22 years of age
• Competent and willing to provide written, informed consent to participate in the study
• A diagnosis of essential tremor as confirmed from clinical history and examination by a movement disorder neurologist
• A tremor severity score of 2 or above in the dominant hand/arm as measured by any one of the TETRAS upper limb items and a minimum subset score of 6 across all upper limb items
• Significant disability due to essential tremor (Bain \& Findley score of 3 or above in any one of the upper limb items and a minimum subset score of 8 across all upper limb items)
• Stable dose of tremor medications, if applicable, for 30 days prior to study entry
• Stable dose of antidepressant medications, if applicable, for 90 days prior to study entry
• Willing to comply with study protocol requirements including:
• remaining on a stable dosage of tremor and antidepressant medications, if applicable, during the duration of the study
• no significant alcohol or caffeine consumption within 8 hours prior to study visits
• no usage of the Cala TWO device within 8 hours prior to study visits

You may not qualify if…

• Moderate to severe ethanol dependence as defined by the criteria outlined in the DSM-5 (score of 4 or higher)
• Implanted electrical medical device, such as a pacemaker, defibrillator, or deep brain stimulator, or implanted metal in the wrist to be stimulated
• Previous thalamotomy procedure, including stereotactic thalamotomy, gamma knife radiosurgical thalamotomy, and focused ultrasound for the treatment of tremor
• Suspected or diagnosed epilepsy or other seizure disorder
• Swollen, infected, inflamed areas, or skin eruptions, open wounds, or cancerous lesions of skin at stimulation site
• Peripheral neuropathy affecting the tested upper extremity
• Presence of any other neurodegenerative disease like Parkinson-plus syndromes suspected on neurological examination. These include: multisystem atrophy, progressive supranuclear palsy, dementia with Lewy bodies, and Alzheimer's disease.
• Anyone suspected to have the diagnosis of idiopathic Parkinson's disease (PD). This includes excluding anyone with the presence of parkinsonian features including bradykinesia rigidity, or postural instability. Subjects who exhibit only mild resting tremor but no other symptoms or signs of PD may be included.
• Botulinum toxin injection for hand tremor within 6 months prior to study enrollment
• Are participating or have participated in another interventional clinical trial in the last 30 days which may confound the results of this study, unless approved by the Sponsor
• Significant alcohol or caffeine consumption within 8 hours prior to study enrollment, which may confound the results of the study, where significant caffeine is considered more than 95 mg (equivalent to a cup of coffee), and significant alcohol is considered more than 14 g (equivalent to 5 oz of wine, 12 oz of beer, or 1.5 oz of distilled spirits).
• Subjects unable to communicate with the investigator and staff
• Any health condition that in the investigator's opinion should preclude participation in this study
• Pregnancy or anticipated pregnancy during the course of the study

Where it is running

• Barrow Neurological Institute (Dignity Health) — Phoenix, Arizona, United States
• USC — Los Angeles, California, United States
• Parkinson's Institute and Clinical Center — Mountain View, California, United States
• University of California San Francisco — San Francisco, California, United States
• Pacific Neuroscience Institute — Santa Monica, California, United States
• Rocky Mountain Movement Disorders Center — Denver, Colorado, United States
• Hospital for Special Care — New Britain, Connecticut, United States
• Medstar Gerogetown Health Institute — Georgetown, District of Columbia, United States
• Parkinson's Center — Boca Raton, Florida, United States
• USF — Tampa, Florida, United States
• Augusta University — Augusta, Georgia, United States
• Rush University Medical Center — Chicago, Illinois, United States
• Kansas University Medical Center — Kansas City, Kansas, United States
• Kaiser Mid-Atlantic Group — Largo, Maryland, United States
• Deaconess Medical Center — Boston, Massachusetts, United States
• Henry Ford Health System — West Bloomfield, Michigan, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Advanced Neurology Specialists — Great Falls, Montana, United States
• Parkinson's Disease and Movement Disorders Center of Long Island — Long Island City, New York, United States
• Mount Sinai & Beth Isreal — New York, New York, United States
• Duke University — Durham, North Carolina, United States
• Wake Forest — Raleigh, North Carolina, United States
• River Hills Neuroscience — Cincinnati, Ohio, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• University Of Pennsylvania Medicine — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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