Dexmedetomidine and Ketamine in VATS Surgery

Recruiting now · Not applicable

Conditions studied: Postoperative Pain, Opioid Use

In brief

Postoperative pain after VATS surgery is significant and associated with moderate to high post operative morphine requirements, which can cause opioid related side effects and delay postoperative recovery. To reduce this requirement, multimodal analgesia with non opioid medication such as dexmedetomidine and ketamine can be used. These drugs have demonstrated significant opioid-sparing properties after various types of surgeries. However, very little is known about their ability to do so in VATS surgery. Also, their relative opioid-sparing properties have not been compared, and it is not known whether their combined use can lead to an additional opioid-sparing effect. The primary goal of this study will be to determine the impact of a combined intra operative infusion of ketamine and dexmedetomidine on postoperative morphine requirements in patients undergoing elective VATS, compared to both these drugs infused separately. The hypothesis is that this combined infusion will lead to a 30% further reduction in morphine requirements, 24h after surgery, compared to both these drugs infused separately.

Key facts

Study ID

NCT03596424

Run by

Ciusss de L'Est de l'Île de Montréal

People needed

120

Starts

2018-02-01

Expected to finish

2026-07-01

Last updated by the study team

2024-12-02

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 18-80 years old
• American Society of Anesthesiology physical status I-III
• Elective Video-Assisted Thoracic Surgery for pulmonary resection

You may not qualify if…

• Patients for which a regional anesthesia technique is planned for postoperative analgesia.
• Patients taking beta-blockers preoperatively.
• Patients with chronic pain taking >60 mg morphine PO daily (or its equivalent).
• Patients taking pregabalin, gabapentin, amitryptillin, nortryptillin and/or duloxetin.
• Documented allergy to ketamine and/or dexmedetomidine.
• Pregnancy
• Inability to give informed consent
• Linguistic barrier.
• Patient refusal

Where it is running

• Ciusss — Montreal, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.