Rectal Administration of Opioids Using the Macy Catheter in Reducing Pain in Patients With Advanced Cancer

Withdrawn before enrolling · Not applicable

Conditions studied: Advanced Malignant Neoplasm, Pain

In brief

This trial studies how well rectal administration of opioids using the Macy catheter works in reducing pain in patients with cancer that has spread to other anatomic sites or is no longer responding to treatment. Rectal administration of opioids using the Macy catheter may help to reduce the cost of care, resolve the issue of medication availability currently faced in the form of parenteral opioid shortage throughout the country, and provide adequate comfort and symptom relief for patients with smoother transition out of hospital.

Key facts

Study ID

NCT03592459

Run by

M.D. Anderson Cancer Center

People needed

0

Starts

2018-08-08

Expected to finish

2020-01-15

Last updated by the study team

2020-11-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients admitted to the inpatient Acute Palliative Care Unit (APCU) at MD Anderson Cancer Center
• Candidate for taking short acting opioids and/or methadone, with or without transdermal fentanyl, for control of cancer related pain
• Impaired oral/gastrointestinal (GI) route for medicine intake (due to, but not limited to, any level of gastrointestinal obstruction, severe nausea and/or vomiting, odynophagia and/or dysphagia due to severe mucositis, tumor, muscle weakness or in-coordination)
• Advanced cancer defined as cancer with no further oncological management and patients are at end of life (EOL) or recommended for best supportive/comfort care (estimated prognosis less than 6 months)
• Able and willing to read and sign in English

You may not qualify if…

• Non-English speaking
• Contraindications to use of the Macy catheter (1. Not be used for patients with rectal lesions, tumors, active rectal bleeding and/or compromised rectal mucosa [i.e. ulceration or ischemic proctitis], 2. Patients with diarrhea, or more than 1 liquid stool per day, 3. Patients with recent bowel surgery [less than 6 weeks], 4. Thrombocytopenia [platelet count less than 20,000, checked in the last 1 week])
• Patients who are unable to take oral medications due to severe constipation only, which can be adequately managed by bowel laxative regimen

Where it is running

• M D Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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