Vagus Nerve Stimulation and Stress Reduction Training for Migraine

Completed · Not applicable · Has a placebo group

Conditions studied: Migraine

In brief

This study design has two components: 1) a cross-sectional assessment of brain activity and inflammation in migraine patients compared to healthy controls and 2) an assessment of 8 weeks of a combination therapy approach to treating migraine.

Key facts

Study ID

NCT03592329

Run by

Massachusetts General Hospital

People needed

193

Starts

2019-08-20

Expected to finish

2025-05-29

Last updated by the study team

2026-02-25

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects must be between 18 and 65 years of age.
• Migraine Diagnosis and general health otherwise.
• Willingness to attend twice- weekly treatment session at Cambridge Health Alliance for 8 weeks.
• Able to give written consent and participate in group interventions in English.
• Healthy Volunteers between the ages of 18 and 65 can participate in this study.

You may not qualify if…

• Major illness, psychiatric condition, or neurological disease.
• Previous experience with stress reduction training (such as mindfulness training, MBSR, MBCT, Relaxation Response) or more than 15 home mediation practice sessions in the past month, or more than 10 classes in yoga, Tai Chi, or Qi Gong in the past 3 months
• Any condition that would prohibit MRI scanning
• Healthy Volunteers have the same eligibility constraints with the addition of current or past history of migraine.

Where it is running

• Anthinoula A. Martinos Center — Charlestown, Massachusetts, United States

Full record on ClinicalTrials.gov

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