Effects of Diet Interventions on Monocytes in Metabolic Syndrome

Completed · Not applicable

Conditions studied: Metabolic Syndrome, Hypertriglyceridemia

In brief

Subjects with hypertriglyceridemia and metabolic syndrome are being recruited and receive diet interventions with either a high-saturated fat diet or a low-fat high protein diet for 4 days (days 1-4) and a breakfast on day 5. Blood samples are collected on day 1 and day 5 to examine lipid levels and circulating monocyte phenotypes.

Key facts

Study ID

NCT03591588

Run by

Baylor College of Medicine

People needed

20

Starts

2016-04-01

Expected to finish

2020-03-31

Last updated by the study team

2020-07-08

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Obese women and men with metabolic syndrome (MS)
• Fasting triglyceride (TG) equal to or greater than 150 mg/dl

You may not qualify if…

• <21 years of age
• Perimenopausal, pregnant or breastfeeding women
• Current smokers
• Obvious inflammation or other acute illnesses
• Obesity due to endocrinologic disorders including polycystic ovary syndrome
• Partial lipodystrophy
• Diabetes requiring insulin or >1 oral medication
• Fasting TG ≥650 mg/dl
• A history of pancreatitis
• Myocardial infarction within the past 3 years
• Any hospitalization within the past 2 months
• Takes steroids.

Where it is running

• Center for Prevention of cardiometabolic disease — Houston, Texas, United States

Full record on ClinicalTrials.gov

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