Blood Flow in Individuals With Down Syndrome

Stopped early · Not applicable

Conditions studied: Down Syndrome

In brief

This study focuses on physiological explanations of difficulties with physical activity and exercise in individuals with Down syndrome, by non-invasively examining cardiac output and the regulation of blood flow to working muscles during exercise.

Key facts

Study ID

NCT03590665

Run by

University of Illinois at Chicago

People needed

21

Starts

2018-03-01

Expected to finish

2019-05-08

Last updated by the study team

2019-07-15

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between 18 and 45 years old
• generally healthy
• sedentary or low-active (defined as being involved in less than 30 minutes of moderately-intense physical activity per day)
• additionally for the participants with Down syndrome:
• diagnosis of Down syndrome trisomy 21 and
• normal thyroid function or stable thyroid function (and medications) for at least 6 months.

You may not qualify if…

• atherosclerotic or other vascular disease;
• asthma or other pulmonary disease;
• hypertension (defined BP >140/90 mmHg);
• blood pressure below 90/60 mmHg;
• history of pre-syncope or syncope;
• diabetes (defined as Hba1c of >7.5% or use of glucose lowering medication);
• severe obesity (defined as BMI >40);
• medications affecting heart rate, blood pressure or arterial function;
• anti-inflammatory medication including NSAIDS;
• current smoking and
• pregnancy.

Where it is running

• Disability, Health, and Social Policy Building, Integrative Physiology Laboratory, Suite 158 at 1640 W. Roosevelt Rd — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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