Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?

Paused · Phase 2 · Has a placebo group

Conditions studied: Alcohol Drinking

In brief

For this protocol, the investigators plan to conduct a pilot study evaluating the effect of propranolol on alcohol consumption. Using a parallel design, the investigators plan to randomize 20 non-treatment seeking adults with alcohol use disorders (DSM-5) to propranolol extended release (160mg/day or placebo; n=10 per cell) to evaluate whether propranolol reduces alcohol self-administered in the laboratory. Importantly, the investigators will evaluate whether propranolol counteracts stress-induced effects on alcohol self-administration. Following titration to steady state medication levels over a 2-week period, each subject will complete two laboratory sessions consisting of a well validated method for inducing stress or neutral/relaxing state (order counterbalanced), followed by a 2-hour alcohol self-administration paradigm known to be sensitive to medication effects.

Key facts

Study ID

NCT03588754

Run by

Yale University

People needed

20

Starts

2018-09-15

Expected to finish

2027-08-31

Last updated by the study team

2026-06-08

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 21-65
• Able to read and write English
• Meets Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for current (past 6 months) alcohol use disorders
• Able to take oral medications and willing to adhere to medication regimen

You may not qualify if…

• Participants with any significant current medical conditions.
• Women who are pregnant or nursing, or fail to use one of the following methods of birth control unless she or partner is surgically sterile or she is postmenopausal (hormone contraceptives [oral, implant, injection, patch, or ring], contraceptive sponge, double barrier [diaphragm or condom plus spermicide], or IUD)
• Suicidal, homicidal or evidence of current (past 6-month) mental illness.
• Specific exclusions for administration of propranolol not already specified.
• Subjects likely to exhibit clinically significant alcohol withdrawal during the study.

Where it is running

• Yale University School of Medicine — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.