Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude
Completed · Not applicable · Has a placebo group
Conditions studied: Intermittent Hypoxia
In brief
Low oxygen at altitude causes pauses in breathing during sleep, called central sleep apnea. Central sleep apnea causes repeated awakenings and poor sleep. Low oxygen itself and the induced oxidative stress can damage mental function which is likely worsened by poor sleep. Reduced mental function due to low oxygen can pose a serious danger to mountain climbers. However there is also mounting evidence that even in populations of people that live at high altitudes and are considered adapted, low oxygen contributes to reductions in learning and memory. Therefore there is a serious need for treatments which may improve sleep, control of breathing and mental function during low oxygen.Therefore this study aims to determine how melatonin effects control of breathing, sleep and mental performance during exposure to low oxygen.
Key facts
- Study ID
- NCT03588676
- Run by
- Robert L. Owens
- People needed
- 39
- Starts
- 2018-01-10
- Expected to finish
- 2018-12-10
- Last updated by the study team
- 2019-08-14
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy Males and Females
- Age:18-65 years
You may not qualify if…
- Sleep Disorders
- Pregnant Females
- Smokers (quit ≥ 1 year ago acceptable)
- Cardiovascular, Pulmonary, Renal, Neurologic, Neuromuscular, or Hepatic Issues
- Diabetes
- Psychiatric disorder, other than mild depression
- Recent exposure to altitude (>8000ft) in the last month or having slept at an altitude >6000ft in the last month
Where it is running
- University of California, San Diego — San Diego, California, United States
Full record on ClinicalTrials.gov
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