Vancomycin De-escalation Therapy in Patients With Pneumonia

Status unconfirmed

Conditions studied: Pneumonia

In brief

This is a non-inferiority study evaluating clinical improvement rate when using MRSA nasal swabs to guide discontinuation of vancomycin for empiric coverage for MRSA pneumonia.

Key facts

Study ID

NCT03586362

Run by

CAMC Health System

People needed

278

Starts

2018-02-08

Expected to finish

2023-12-30

Last updated by the study team

2022-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >= 18 years old
• Patients admitted to Charleston Area Medical Center (CAMC) through the Emergency Department who meet the CDC criteria for pneumonia.
• Nasal surveillance culture for MRSA obtained in the Emergency Department
• Patients receiving vancomycin and additional antibiotic therapy for gram-negative coverage

You may not qualify if…

• Persistent vasopressor requirements when MRSA nasal swab results are available
• Patients not meeting the CDC criteria for pneumonia
• Patients presenting to the ED with leukopenia (≤4000) without previous documentation of normal or elevated WBC
• Patients receiving empiric MRSA antibiotic therapy other than vancomycin for pneumonia
• Patients with the diagnosis of lung abscess
• Patients not receiving vancomycin therapy before MRSA nasal swab results are reported
• Immunocompromised individuals. i.e. patients with AIDS/HIV, vasculitis on immune suppressor therapy, steroid therapy for more than one week prior admission or who received chemotherapy in the last 3 months
• Patients who do not have a MRSA nasal swab obtained in the ED
• Nares swab obtained after the completion of the first administered dose of an antibiotic with activity against MRSA
• Patients with MRSA bacteremia
• Patients with chronic tracheostomy

Where it is running

• Charleston Area Medical Center — Charleston, West Virginia, United States

Full record on ClinicalTrials.gov

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