Brain Response Associated With Parent-based Treatment for Childhood Anxiety Disorders

Completed · Not applicable

Conditions studied: Anxiety Disorder of Childhood, Separation Anxiety Disorder of Childhood, Social Anxiety Disorder of Childhood, Generalized Anxiety Disorder

In brief

This study aims to investigate whether a parent-based treatment for childhood anxiety disorders engages child brain circuitry implicated in children's reliance on parents to reduce anxiety (R61), and whether change in child brain circuitry is associated with reduction in child anxiety (R33).

Key facts

Study ID

NCT03585010

Run by

Yale University

People needed

214

Starts

2018-08-24

Expected to finish

2024-03-31

Last updated by the study team

2026-04-22

Who can join

Age: 6 and older, up to 12. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Prepubertal
• Clinical diagnosis of primary anxiety disorder
• Must not have another mental illness more impairing than the most impairing anxiety disorder
• IQ of at least 80.

You may not qualify if…

• Neurological disorders (including seizures)
• Organic mental disorders, psychotic disorders, or pervasive developmental disorders
• High likelihood of hurting themselves or others
• Current psychosocial or psychopharmacological treatment
• History of neurological illness or head injury with loss of consciousness > 5 minutes
• Vision or physical disability that interferes with seeing stimuli presented briefly on computer screen and/or clicking a mouse button rapidly and repeatedly
• Contraindications for MRI scanning (e.g., metal implants, pacemakers, braces, claustrophobia, pregnancy, weight > 250 pounds).

Where it is running

• Yale University Child Study Center — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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