Multicenter Randomized Trial of 68Ga-PSMA-11 PET/CT Based SRT After Radical Prostatectomy

Running, not enrolling · Phase 3

Conditions studied: Recurrent Prostate Carcinoma

In brief

This phase III trial studies how well Gallium Ga 68-labeled PSMA-11 (68Ga-PSMA-11) positron emission tomography (PET)/computed tomography (CT) works in diagnosing participants with prostate cancer that has come back after surgery. 68Ga-PSMA-11 are taken up by cancer cells. Diagnostic procedures, such as PET/CT scans, may help find and diagnose prostate cancer and find out how far the disease has spread. Giving 68Ga-PSMA-11 with PET/CT may help doctors plan better for salvage radiation therapy in participants with recurrent prostate cancer.

Key facts

Study ID

NCT03582774

Run by

Jonsson Comprehensive Cancer Center

People needed

193

Starts

2018-07-12

Expected to finish

2028-07-12

Last updated by the study team

2026-05-26

Who can join

Age: any. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Histopathology proven prostate cancer.
• Planned SRT for recurrence after primary prostatectomy.
• Prostate-specific antigen (PSA) >= 0.1 ng/ml at time of enrollment.
• Willingness to undergo radiotherapy.
• Treating radiation oncologist intends to incorporate 68Ga-PSMA-11 PET/CT findings into the radiotherapy plan if patient undergoes 68Ga-PSMA-11 PET/CT.

You may not qualify if…

• Extra-pelvic metastasis on any imaging or biopsy.
• Androgen deprivation therapy (ADT) within 3 months before 68Ga-PSMA-11 PET/CT.
• Contraindications to radiotherapy (including active inflammatory bowel disease).
• Concurrent systemic therapy for prostate cancer with investigational agents.

Where it is running

• UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California, United States
• UCSF Medical Center-Mount Zion — San Francisco, California, United States

Full record on ClinicalTrials.gov

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