Nicotine TMS EFT Smoking Pilot Study

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Smoking, Nicotine Dependence, Addiction, Smoking, Cigarette

In brief

Prior and recent evidence suggests a role of medial prefrontal cortex (MPFC) in cigarette smoking. Episodic Future Thinking (EFT) has also been shown to be associated with increased delayed discounting and reduced cigarette self administration. In the present study, we will examine whether a single administration of theta-burst transcranial magnetic stimulation (tbTMS) can increase Episodic Future Thinking and delayed discounting while reducing craving for nicotine.

Key facts

Study ID

NCT03579953

Run by

Medical University of South Carolina

People needed

16

Starts

2018-05-22

Expected to finish

2019-06-10

Last updated by the study team

2019-08-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-65 years of age
• Smoke at least 10 cigarettes a day (on average)
• Not be pregnant
• Meet all criteria on a standardized TMS safety screen (including to but not limited to implanted electronic devices, bullets or metallic fragments above the neck, hair clips that cannot be removed)
• No barriers to making contact between the TMS coil and the skin (e.g. cornrows that cannot be removed, glasses that the participant is unwilling to remove)

You may not qualify if…

• Report comorbid mental or physical illness (managed or unmanaged)
• Currently using prescription medication that might affect smoking or nicotine metabolism
• Using smokeless tobacco or alternative nicotine products
• History of epilepsy or seizures (other than childhood febrile seizures)
• History of chronic migraines

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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