The Effect of Sugammadex Versus Neostigmine During Neuromuscular Blockade Reversal

Completed · Phase 1

Conditions studied: Neuromuscular Blockade

In brief

Patients who undergo surgery receive drugs called neuromuscular blocking agents (NMBA) that to block the activity of muscles. When the surgery is over, the block needs to be reversed. Suggammadex and neostigmine are examples of drugs that reverse blocks. This study aims to investigate if sugammadex is associated with a significantly reduced time to discharge from the operating room to the postoperative unit when compared to neostigmine.

Key facts

Study ID

NCT03579589

Run by

Ohio State University

People needed

40

Starts

2018-08-15

Expected to finish

2019-12-15

Last updated by the study team

2021-08-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects undergoing outpatient surgeries (laparoscopic cholecystectomy, laparoscopic hernia repair, laparoscopic appendectomy) under general anesthesia requiring rocuronium-induced neuromuscular blockade
• Male or female patient 18 years and older
• Able to consent
• American Society of Anesthesiologist (ASA) physical status of I, II, or III

You may not qualify if…

• Participating in another interventional study drug within 30 days prior to their recruitment
• Special population (Pregnant, Inmate, Breastfeeding)
• History of allergy to sugammadex or rocuronium
• Any medication known to interfere with NMBA or sugammadex
• Presence of any clinical condition as determined by the investigator that exclude the patient from the trial such as COPD, CKD, and neuromuscular or neurodegenerative diseases

Where it is running

• The Ohio State University Wexner Medical Center — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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