Caffeine and Neurologic Recovery Following Surgery and General Anesthesia

Completed · Early Phase 1

Conditions studied: Pain, Postoperative

In brief

The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may reduce pain after surgery. Thus, the purpose of this study is to test whether caffeine reduces pain and opioid requirements after surgery. The investigators will also test whether caffeine improves mood and brain function (e.g., learning, memory) after surgery.

Key facts

Study ID

NCT03577730

Run by

University of Michigan

People needed

71

Starts

2018-07-10

Expected to finish

2020-01-17

Last updated by the study team

2021-10-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (>/= 18 years old) undergoing non-cardiac, non-neurologic, non-major vascular surgery requiring general anesthesia

You may not qualify if…

• Emergency surgery
• Cognitive impairment precluding capacity for informed consent
• Uncontrolled cardiac arrhythmias
• Seizure disorders
• Preoperative opioid use
• Diabetes
• Liver failure
• Pregnancy
• Breastfeeding
• Severe visual or auditory impairment (may hinder cognitive function testing)
• Patients unable to speak English.

Where it is running

• Michigan Medicine — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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