MRS to Determine Neuroinflammation and Oxidative Stress in MPS I

Completed

Conditions studied: Mucopolysaccharidosis Type I

In brief

Neuroinflammation and oxidative stress have been shown to be present in persons with mucopolysaccharidosis type I (MPS I), but their effect on disease severity and disease progression is unknown. The investigator intends to employ brain magnetic resonance spectroscopy (MRS), a non-invasive technique, along with analysis of neuroinflammation and oxidative stress biomarkers in the blood, to measure and determine the level of oxidative stress and neuroinflammation, and their impact on clinical variability in MPS I patients.

Key facts

Study ID

NCT03576729

Run by

University of Minnesota

People needed

30

Starts

2018-11-01

Expected to finish

2019-08-31

Last updated by the study team

2019-11-01

Who can join

Age: 6 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• MPS I participants must meet the following:
• Diagnosis of Hurler syndrome, OR Hurler-Scheie syndrome, OR Scheie syndrome
• 6 years of age or older at time of screening
• Healthy control participants must meet all of the following:
• Absence of neurological disorder
• 6 years of age or older at time of screening

You may not qualify if…

• Persons who have any of the following will not be enrolled in this study:
• Any surgically implanted pacemaker
• Any indwelling electronic device, including programmable shunts
• Orthodontic braces, unless non-metallic
• Other implanted metal in the body other than titanium
• An inability or unwillingness to complete an MRI/MRS because of low cognitive function or behavioral dysregulation
• Pregnancy

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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