Study Confirming A Human Challenge Model and Investigating The Safety Of VLA1701

Completed · Phase 2 · Has a placebo group

Conditions studied: Enterotoxigenic Escherichia Coli Infection, Diarrhea

In brief

This is a single-center, double-blind, placebo-controlled, Phase II vaccination and challenge study designed to confirm a human challenge model with E. coli strain LSN03-016011/A.

Key facts

Study ID

NCT03576183

Run by

Valneva Austria GmbH

People needed

34

Starts

2018-06-04

Expected to finish

2018-11-30

Last updated by the study team

2021-04-23

Who can join

Age: 18 and older, up to 49. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy male and non-pregnant female subjects aged 18 to <50 years;
• BMI of 19.0 to 35.0 kg/m2
• Willingness to participate after informed consent has been obtained from the subject prior to any study related procedures.
• Completion of a training session and demonstration of comprehension of the protocol procedures and knowledge of ETEC-associated illness by passing a written examination.
• If subject is of childbearing potential:
• Negative pregnancy test at screening with understanding to not become pregnant within 28 days after challenge;
• Subject has practiced an effective method of contraception during the 30 days before screening (Visit 0);
• Subject agrees to employ adequate birth control measures for the duration of the study.

You may not qualify if…

• Participated in research involving investigational product within 30 days before planned date of first vaccination or planned use through Day 44;
• Any prior exposure to ETEC (including LSN03-016011/A) or cholera occupationally or received LT (Or any mutant forms of LT (e.g., LTR192G, LTR192GL211A), ETEC, or cholera vaccine);
• Subjects with known abnormal stooling patterns (fewer than 3 per week or more than 3 per day);
• Known allergies to any component of the vaccine;
• Subjects with known allergies to more than 1 planned antibiotics:
• History of diarrhea while traveling in a developing country within the last 3 years;
• Subjects whose occupation involves handling of ETEC or cholera bacteria;
• Women who are pregnant or breastfeeding;
• Significant medical conditions including chronic, immunosuppressive, malignant, or gastrointestinal diseases (e.g. History of Irritable Bowel Syndrome (as defined by the Rome III criteria or medical diagnosis) or gastric ulcer disease) or enteric, pulmonary, cardiac, liver or renal disease. Some medical conditions which are adequately treated and stable may be acceptable in the study (e.g. hypertension);
• Significant abnormalities in screening lab hematology or serum chemistries;
• Use of any medication known to effect the immune system (e.g. systemic corticosteroids) within 30 days of vaccination or planned use during active study period (excluding inhaled steroids);
• Evidence of confirmed infection with HIV, Hepatitis B or Hepatitis C;
• Subjects with IgA (Immunoglobulin A) deficiency (serum IgA < 7 mg/dl or limit of detection of assay);
• Regular use of antacids, antidiarrheal, loperamide, bismuth subsalicylate, diphenoxylate or similar medication less than 2 weeks prior to enrolling in the study and through the inpatient portion of the study;
• Known or suspected alcohol abuse or illicit drug use within the last year, positive urine toxicology for drugs of abuse;
• Persons who are committed to an institution (by virtue of an order issued either by the judicial or the administrative authorities);
• Persons who are in a dependent relationship with the sponsor, an investigator or other study team members, or the study center.
• Any other criteria which, in the investigator's opinion, would compromise the ability of the subject to participate in the study, the safety of the study, or the results of the study.

Where it is running

• Department of International Health Johns Hopkins University — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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