Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)

Recruiting now · Not applicable

Conditions studied: Kidney Failure, Chronic, Hyperphosphatemia

In brief

During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.

Key facts

Study ID

NCT03573089

Run by

The University of Queensland

People needed

3600

Starts

2019-12-10

Expected to finish

2028-12-31

Last updated by the study team

2025-07-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥45 years, or Age ≥18 years with diabetes,
• ESKD on haemodialysis or peritoneal dialysis, for at least 3 months,
• Currently prescribed at least one phosphate-lowering medication at any dose
• Able to provide informed consent

You may not qualify if…

• Elective kidney transplantation scheduled,
• Concomitant major illness / comorbidity that may result in death in the next 6 months in the view of the treating physician,
• Participation in an interventional study that is likely to affect serum phosphate concentration.

Where it is running

• Scarborough Hospital Network — Scarborough Village, Ontario, Canada (enrolling)
• Hopital Maisonneuve Rosemont — Montreal, Quebec, Canada (enrolling)
• Dalhousie University — Halifax, Nova Scotia, Canada (enrolling)
• Mackenzie Health — Richmond Hill, Ontario, Canada (enrolling)
• St. Joseph's Healthcare Hamilton — Toronto, Ontario, Canada (enrolling)
• McGill University Health Centre — Montreal, Quebec, Canada (enrolling)
• Hospital Alemao Oswaldo Cruz — São Paulo, Brazil (enrolling)
• St. Paul's Hospital — Vancouver, British Columbia, Canada (enrolling)
• Oakville Trafalgar Memorial Hospital — Oakville, Ontario, Canada (enrolling)
• The Ottawa Hospital — Ottawa, Ontario, Canada (enrolling)
• St Michael's Hospital — Toronto, Ontario, Canada (enrolling)
• University Health Network - University of Toronto — Toronto, Ontario, Canada (enrolling)
• St. Joseph's Healthcare Toronto — Toronto, Ontario, Canada (enrolling)
• The Charles Lemoyne Hospital — Longueuil, Quebec, Canada (enrolling)
• Hospital de Clinicas Porto Alegre — Porto Alegre, Rio Grande do Sul, Brazil (enrolling)
• Fundacao Felice Rosso - Hospital Felicio Rocho — Barro Preto, Brazil (enrolling)
• Foothills Hospital/ U of Calgary — Calgary, Alberta, Canada (enrolling)
• Alberta Health Services — Edmonton, Alberta, Canada (enrolling)
• Queen's University — Kingston, Ontario, Canada (enrolling)
• London Health Sciences Centre — London, Ontario, Canada (enrolling)
• Orillia Soldier's Memorial Hospital — Orillia, Ontario, Canada (enrolling)
• Lakeridge Health — Oshawa, Ontario, Canada (enrolling)
• BRA Santa Casa de Misericórdia de Ponta Grossa — Ponta Grossa, Paraná, Brazil (enrolling)
• Sociedade Hospitalar Angelina Caron — Campina Grande, Paraíba, Brazil (enrolling)
• CHUM — Montreal, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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