Imaging of Coronary Plaques in Participants Treated With Evolocumab

Completed · Phase 3 · Has a placebo group

Conditions studied: Coronary Artery Disease (CAD)

In brief

To evaluate the effect of evolocumab on fibrous cap thickness (FCT) in participants with non-ST-elevation acute coronary syndrome (NSTE-ACS) who are taking maximally tolerated statin therapy.

Key facts

Study ID

NCT03570697

Run by

Amgen

People needed

164

Starts

2018-11-19

Expected to finish

2021-01-21

Last updated by the study team

2022-05-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provided informed consent prior to initiation of any study-specific activities/procedures.
• Age greater than or equal to 18 years at screening
• Clinical indication for coronary angiography during admission due to NSTE-ACS with interventional treatment of culprit plaque
• An eligible low-density lipoprotein cholesterol (LDL-C) level via local lab assessment based on statin use at screening
• No statin use: greater than or equal to 130 mg/dL Low- or moderate-intensity statin use greater than or equal to 80 mg/dL High-intensity statin use greater than or equal to 60 mg/dL
• On maximally tolerated statin therapy in accordance with standard of care per local guidelines prior to randomization.
• Tolerates placebo run-in injection at screening
• Meets all the following criteria at the qualifying coronary angiogram:
• Angiographic evidence of coronary artery disease (CAD) with greater than or equal to 20% reduction of lumen diameter by angiographic visual estimation, in addition to the culprit plaque.
• Left main coronary artery must not have a greater than 50% reduction in lumen diameter by visual angiographic estimation.
• Targeted vessel:
• May not be the culprit vessel for the current or a previous myocardial infarction (MI).
• Has not undergone prior percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), and may not be a bypass graft.
• May not be a candidate for PCI or CABG currently or over the next 12 months, in the opinion of the investigator.
• Must be accessible by the optical coherence tomography (OCT) catheter.
• Targeted segment:
• Must have up to 50% but not greater than 50% reduction in lumen diameter by visual angiographic estimation and must be at least 40 mm in length.
• Must contain at least 1 image with a fibrous cap thickness (FCT) of less than or equal to 120 μm and at least 1 image with a lipid arc of greater than 90° as determined by the imaging core laboratory Distal plaques of up to 50% stenosis by visual angiographic estimation are permitted, provided that such stenosis is not a target for PCI or CABG.

You may not qualify if…

• ST-segment elevation myocardial infarction (STEMI) or left bundle branch block (LBBB).
• Acute coronary syndromes (ACS) likely to be caused by a non-atherosclerotic process, in the opinion of the investigator (ie, type 2 myocardial infarction, which is characterized by an imbalance between myocardial oxygen demand and supply).
• Clinically significant heart disease which in the opinion of the investigator is likely to require coronary bypass surgery, PCI (does not apply to PCI of non-STEMI (NSTEMI) during initial screening angiogram), surgical or percutaneous valve repair and/or replacement during the course of the study.
• Any cardiac surgery within 6 weeks prior to screening.
• Triglycerides greater than or equal to 400 mg/dL (4.5 mmol/L) at screening.
• Moderate to severe renal dysfunction, defined as an estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73m\^2 at screening.
• Malignancy except non-melanoma skin cancers, cervical, or breast ductal carcinoma in situ within the last 5 years.
• Intolerant to statins as determined by principal investigator.
• Previously received or receiving evolocumab or any other therapy to inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9).
• Previously received a cholesterol ester transfer protein (CETP) inhibitor (ie, anacetrapib, dalcetrapib, evacetrapib), mipomersen, lomitapide, or has undergone LDL-apheresis in the last 12 months prior to LDL-C screening.
• Currently receiving treatment in another investigational device or drug study, or less than 30 days since ending treatment on another investigational device or drug study(ies). Other investigational procedures while participating in this study are excluded.
• Baseline OCT does not meet OCT imaging criteria as determined by the imagine core laboratory technical standards.
• Female subject is pregnant or breastfeeding or planning to become pregnant or breastfeed during treatment and for an additional 15 weeks after the last dose of investigational product. (Females of childbearing potential should only be included in the study after a confirmed menstrual period and a negative highly sensitive urine or serum pregnancy test.)
• Female subjects of childbearing potential unwilling to use 1 acceptable method of effective contraception during treatment and for an additional 15 weeks after the last dose of investigational product.
• Female subject who has not used an acceptable method(s) of birth control for at least 1 month prior to screening, unless the female subject is sterilized or postmenopausal.
• Known sensitivity to any of the products or components (eg, carboxymethylcellulose) to be administered during dosing.

Where it is running

• University of California at Los Angeles — Los Angeles, California, United States
• Medstar Heart and Vascular Institute — Washington D.C., District of Columbia, United States
• Midwest Cardiovascular Research And Education Foundation — Elkhart, Indiana, United States
• Saint Louis University Hospital — St Louis, Missouri, United States
• University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
• Royal Prince Alfred Hospital — Camperdown, New South Wales, Australia
• Royal North Shore Hospital — St Leonards, New South Wales, Australia
• Royal Adelaide Hospital — Adelaide, South Australia, Australia
• Monash Medical Centre — Clayton, Victoria, Australia
• The Northern Hospital — Epping, Victoria, Australia
• Fakultni nemocnice Brno — Brno, Czechia
• Fakultni nemocnice Hradec Kralove — Hradec Králové, Czechia
• Charite Universitätsmedizin Berlin Campus Benjamin Franklin — Berlin, Germany
• Universitäres Herzzentrum Hamburg GmbH — Hamburg, Germany
• Deutsches Herzzentrum München des Freistaates Bayern — München, Germany
• Allami Szivkorhaz Balatonfured — Balatonfüred, Hungary
• Semmelweis Egyetem — Budapest, Hungary
• Magyar Honvedseg Egeszsegugyi Kozpont — Budapest, Hungary
• Pecsi Tudomanyegyetem Klinikai Kozpont — Pécs, Hungary
• Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII — Bergamo, Italy
• Azienda Ospedaliera Santa Croce e Carle — Cuneo, Italy
• Azienda Ospedaliera Universitaria Careggi — Florence, Italy
• IRCCS Centro Cardiologico Monzino — Milan, Italy
• Azienda Ospedaliera Universitaria Federico II — Naples, Italy
• Azienda Ospedaliera San Giovanni Addolorata — Roma, Italy

Full record on ClinicalTrials.gov

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