A Pilot Study Assessing the Treatment Responsiveness of a Novel Osteoarthritis Stiffness Scale

Completed · Phase 2 · Has a placebo group

Conditions studied: Osteoarthritis, Knee

In brief

Osteoarthritis is a common, chronic, progressive, skeletal, degenerative disorder that frequently affects several joints such as knee, hip, spine and hands.This placebo-controlled clinical trial assessed the effects of naproxen sodium, acetaminophen and celecoxib on stiffness in subjects with osteoarthritis.

Key facts

Study ID

NCT03570554

Run by

Bayer

People needed

41

Starts

2018-06-29

Expected to finish

2019-06-14

Last updated by the study team

2020-06-19

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 40 and 80 years
• Body Mass Index (BMI) between 18 and <40 kg/m\^2
• Unilateral or bilateral osteoarthritis of the knee
• Diagnostic quality radiography of the target knee performed no more than 1 year prior to baseline showing evidence of osteoarthritis (OA) with Kellgren and Lawrence grade of II or III
• Joint Stiffness Severity score ≥3.0 on a 0-10 numerical rating scale (NRS) at screening

You may not qualify if…

• History of underlying inflammatory arthropathy, rheumatoid arthritis or fibromyalgia
• History of or scheduled for target knee replacement surgery
• Recent injury in target knee (past 4 months)

Where it is running

• Radiant Research, Inc. — Chandler, Arizona, United States
• Radiant Research, Inc. — Pinellas Park, Florida, United States
• Radiant Research, Inc. — Chicago, Illinois, United States
• Radiant Research, Inc. — Cincinnati, Ohio, United States
• Radiant Research, Inc. — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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