Modeling and Closed-loop Control of Depth of Anaesthesia

Recruiting now

Conditions studied: The Focus is to Develop a Closed-loop Control System for Anaesthesia in Vitroretinal Surgery, Surgery Due to Expansive Processes in Head, and Long-term Sedation

In brief

The study evaluates the effect of anaesthetic agents to depth of anaesthesia. An improved PK-PD model wil be developed that will provide the basis for understanding the mechanisms, simulating various scenarios and developing algorithms for better and safer administration of anaesthetic agents.

Key facts

Study ID

NCT03569839

Run by

University of Ljubljana

People needed

50

Starts

2017-09-14

Expected to finish

2028-12-01

Last updated by the study team

2026-05-11

Who can join

Age: 20 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• patients having vitroretinal surgery in general anaesthesia
• patients having brain surgery in general anaesthesia
• patients needing sedation in ICU
• ASA 1-3

You may not qualify if…

• ASA > 3
• BMI > 35
• drug addicts
• patients taking psychotropic medicines
• patients taking opioid analgesics (including tramadol)
• severe psychiatric disease
• central nervous system disease (except the reason for surgery)
• arrhythmia affecting or preventing the measurements (e.g. chronic atrial fibrillation)
• patients that received benzodiazepines

Where it is running

• University Medical Centre Ljubljana — Ljubljana, Ljubljana, Slovenia (enrolling)

Full record on ClinicalTrials.gov

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