Individualized vs Low PEEP in One Lung Ventilation

Withdrawn before enrolling · Not applicable

Conditions studied: One-Lung Ventilation, Obesity, Lung Diseases

In brief

The aim of the prospective crossover study is to investigate the effect of individualized positive end-expiratory pressure (PEEP) on measures of tissue oxygenation, compared with low PEEP.

Key facts

Study ID

NCT03569774

Run by

Dionne Peacher

People needed

0

Starts

2018-08-14

Expected to finish

2021-05-19

Last updated by the study team

2021-07-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject undergoing elective pulmonary lobectomy requiring one-lung ventilation
• Body-mass index ≥ 30 kg/m2
• Age ≥ 18 years and ≤ 80 years

You may not qualify if…

• Age ≤ 18 year or ≥ 80 years
• Moderate or severe cardiac valvular disease
• Left ventricular ejection fraction < 30%
• Moderate or severe right ventricular systolic dysfunction
• Severe pulmonary hypertension
• Presence of pulmonary bullae or blebs on preoperative chest imaging studies (e.g., radiograph, computed tomograph)
• Emergency surgery
• Previous history of lung surgery on the non-operative lung
• Pregnancy
• Incarceration
• Mental incapacitation
• Patient refusal
• Non-English speaking

Where it is running

• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States

Full record on ClinicalTrials.gov

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