Efficacy, Safety, and Tolerability of Levomilnacipran ER in Pediatric Patients (7-17 Years) With Major Depressive Disorder

Completed · Phase 3 · Has a placebo group

Conditions studied: Major Depressive Disorder

In brief

The objective of this study is to evaluate the efficacy, safety, and tolerability of levomilnacipran compared with placebo in pediatric outpatients (7-17 years) with major depressive disorder (MDD).

Key facts

Study ID

NCT03569475

Run by

Allergan

People needed

501

Starts

2018-07-06

Expected to finish

2021-03-01

Last updated by the study team

2022-03-25

Who can join

Age: 7 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must meet Diagnostic and statistical manual of mental disorders fifth edition (DSM-5) criteria for MDD, confirmed by Kiddie Schedule for Affective Disorders - Present and Lifetime (K-SADS-PL)
• Patients must have a score ≥ 40 on the Children's Depression Rating Scale-Revised (CDRS-R) at Visits 1 and 2
• Patients must have a Clinical Global Impressions-Severity (CGI-S) score ≥ 4 at Visits 1 and 2
• Patients must have a caregiver who can and is willing to consent to be responsible for safety monitoring of the Patient, provide information about the patient's condition, oversee the administration of investigational product, and accompany the patients to all study visits
• Female patients of childbearing potential who are sexually active must agree to use a reliable method of contraception that will continue for the duration of the study and within 30 days following the end of study participation.
• A sexually active male patients must agree to use contraception as detailed below during the treatment period and for at least 30 days after the last dose of investigational product.

You may not qualify if…

• DSM-5-based diagnosis of an axis I disorder other than MDD that is the primary focus of treatment.
• Prior diagnosis of mental retardation or amnestic or other cognitive disorders based on DSM-5 criteria
• Imminent risk of injuring self or others or causing damage to property as judged by the Investigator
• Suicide risk as determined by meeting either of the following criteria:
• Any suicide attempt within the past year
• Significant risk at Visit 1 (Screening) or Visit 2 (Baseline), as judged by the Investigator based on the psychiatric interview or information collected in the Columbia-Suicide Severity Rating Scale (C-SSRS) treatment-Related Criteria
• History of allergy, intolerance, or hypersensitivity to levomilnacipran, milnacipran, fluoxetine, or any other Selective serotonin reuptake inhibitors (SSRI) or Serotonin and norepinephrine reuptake inhibitors (SNRI) or known hypersensitivity to the investigational products' non-medicinal ingredients including gelatin and cellulose
• Patients requiring prohibited concomitant medication or herbal supplements that could not be discontinued or switched to an allowable alternative medication and stabilized for at least 2 weeks preceding Visit 2 (Baseline)
• Patients taking any psychoactive drug or psychoactive herbal remedy within 5 half-lives before Baseline (Visit 2), Patients who have ever been treated with a depot antipsychotic must also be excluded
• Patients who have initiated or terminated psychotherapy or behavior therapy within1 month before Visit 1 (Screening), or who plan to initiate or change such therapies during the course of the study Other Medical criteria
• A clinically significant disease state that, in the investigator's opinion, might indicate that the patients is unsuitable for the study
• Any cardiovascular disease or condition that is clinically significant, unstable, or decompensated.
• Hypo- or hyperthyroidism, unless stabilized on appropriate pharmacotherapy with no change in dosage for at least 3 months before Visit 1 (Screening)
• Any condition that would be expected to affect drug absorption (eg, gastric bypass surgery)
• History of seizure disorder (except simple childhood febrile seizures before age 5), unexplained syncope or black-out episodes, stroke, significant head injury, tumor of the central nervous system, or any other condition that predisposes the patient toward a risk for seizure
• History of drug or alcohol abuse or dependence within the past year
• Pregnant, breastfeeding, and/or planning to become pregnant and/or breastfeed during the study or within 30 days following the end of study participation
• Patients who are unable to swallow capsules
• Treatment with any investigational product within 3 months (or at least 5 half-lives, whichever is longer) of Visit 1. Treatment with any investigational product other than those provided by AGN during study participation will be a protocol violation, and the patient will be terminated from this study
• Employee or immediate relative of an employee of Allergan (AGN), any of its affiliates or partners, or of the study center
• Patients or patients whose parent/guardian/ legally authorized representative (LAR) and/or caregivers are unable to speak and understand English (or their native language if this can be accommodated by the site and is approved by the Sponsor) sufficiently to understand the nature of the study, to provide informed assent/consent, or to allow the completion of all study assessments
• Unable or unlikely to comply with the study protocol or are unsuitable for any other reason, Other Criteriaas judged by the Investigator

Where it is running

• Care Access Research, Beverly Hills — Beverly Hills, California, United States
• Kindred Medical Institute for Clinical Trials, LLC — Corona, California, United States
• Behavioral Research Specialists, LLC — Glendale, California, United States
• Sun Valley Research Center — Imperial, California, United States
• Alliance Research — Long Beach, California, United States
• Excell Research, Inc. — Oceanside, California, United States
• NRC Research Institute — Orange, California, United States
• Elite Clinical Trials, Inc. — Wildomar, California, United States
• Children's National Health System — Washington D.C., District of Columbia, United States
• Advanced Research Institute of Miami — Homestead, Florida, United States
• Clinical Neuroscience Solutions, Inc — Jacksonville, Florida, United States
• Zynak Clinical — Lauderdale Lakes, Florida, United States
• Columbus Clinical Services, LLC — Miami, Florida, United States
• Clinical Neuroscience Solutions, Inc. — Orlando, Florida, United States
• Atlanta Center for Medical Research — Atlanta, Georgia, United States
• Atlanta Behavioral Research, LLC — Atlanta, Georgia, United States
• iResearch Atlanta — Decatur, Georgia, United States
• Attalla Consultants, LLC — Smyrna, Georgia, United States
• Clinical Research Institute — Stockbridge, Georgia, United States
• Inova Clinical trials and Research Center — Tyrone, Georgia, United States
• Advanced Clinical Research — Meridian, Idaho, United States
• Capstone Clinical Research — Libertyville, Illinois, United States
• AMR Conventions Limited — Naperville, Illinois, United States
• AMR-Baber Research, Inc. — Naperville, Illinois, United States
• Woodland International Research Group — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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