Children and Adolescents With Marfan Syndrome: 10,000 Healthy Steps and Beyond
Completed · Not applicable
Conditions studied: Marfan Syndrome
In brief
Marfan patients are at risk of sudden death due to weakening of the wall of the large blood vessel leading from the heart (aorta). The wall of the aorta weakens and dilates which can rupture, leading to death, and sometimes during intense exercise. There is some evidence in Marfan patients that a stiffer aorta increases risk for rupture. For some time, clinical care has focused on what type of exercise these patients should avoid due to risk for aortic dissection. Little clinical emphasis has been placed on encouraging patients to engage in routine and safe exercise such as walking. Informed by this evidence, the investigators propose to collaboratively investigate whether regular exercise improves aortic health in adolescent Marfan patients.
Key facts
- Study ID
- NCT03567460
- Run by
- Stanford University
- People needed
- 24
- Starts
- 2017-01-01
- Expected to finish
- 2019-12-31
- Last updated by the study team
- 2020-07-27
Who can join
Age: 10 and older, up to 19. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 10-19 years of age,
- MFS by revised Ghent criteria,
- Cardiac clearance to exercise by the primary cardiologist.
You may not qualify if…
- Ventricular dysfunction,
- Prior history of aortic surgery.
Where it is running
- Stanford Children's Health — Palo Alto, California, United States
Full record on ClinicalTrials.gov
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