Alcohol and Neural Cardiovascular Control in Binge Drinkers
Completed · Not applicable · Has a placebo group
Conditions studied: Binge Drinking
In brief
This study evaluates the impact of evening alcohol consumption on sympathetic activity and baroreflex function in binge drinkers. Our central hypothesis is that evening binge alcohol consumption will lead to sympathetic overactivity and blunted baroreflex function.
Key facts
- Study ID
- NCT03567434
- Run by
- Baylor University
- People needed
- 69
- Starts
- 2018-05-21
- Expected to finish
- 2022-07-01
- Last updated by the study team
- 2024-09-24
Who can join
Age: 21 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women age 21 - 40 years
- Binge drinkers as defined by a pattern of consuming ≥4 drinks if female (≥5 drinks if males) in ≤ 2 hours on more than one occasion within the past 6 months, and at least once in the past 30 days. The National Institute of Alcohol Abuse and Alcoholism (NIAAA) definition of a "drink" will be used.
- Women must be eumenorrheic and premenopausal with regular and consistent menstrual cycles (i.e., \~25-30 days ovarian/uterine cycles that include 2-7 days of menstruation)
- Willingness to abstain from exercise and caffeine at least 12 hours prior to any autonomic and cardiovascular testing, and abstain from alcohol 24 hours prior to any autonomic and cardiovascular testing (unless experimentally administered).
You may not qualify if…
- Body mass index ≥ 35 kg/m2
- Smokers
- A physician diagnosis of diabetes
- Pregnancy
- Taking any cardiovascular medications
- Severe obstructive sleep apnea as determined by an apnea-hypopnea index of ≥ 30 episodes per hour
- Moderate-to-severe Alcohol Use Disorder (AUD) as determined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-V)
- Individuals suspected to have mutant alcohol dehydrogenase 2 (ALDH2) isoenzyme as determined using a validated flushing questionnaire
- Women using hormonal contraceptives (i.e., oral, intrauterine, etc.) in the prior 6 months
Where it is running
- Montana State University — Bozeman, Montana, United States
Full record on ClinicalTrials.gov
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