Secondary Sclerosis Cholangitis Prospective

Recruiting now

Conditions studied: Secondary Sclerosis Cholangitis in Critically Ill Patients

In brief

SC-CIP is increasing in patients after critical illness. Pathogenesis is still largely unclear. Gut microbiome composition, gut permeability, bacterial translocation, inflammation and/or genetic variants contribute to the pathogenesis The aim of this project is to study gut microbiome composition, gut permeability, bacterial translocation, inflammation, bile acid composition and genetic polymorphisms by conducting a prospective cohort study in patients with a high risk to develop SC-CIP.

Key facts

Study ID

NCT03566797

Run by

Medical University of Graz

People needed

380

Starts

2018-07-20

Expected to finish

2027-12-01

Last updated by the study team

2024-10-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant is willing and able to give informed consent for participation in the study OR "surrogate consent" by the institutional review board.
• Age above 18 years
• Mechanical ventilation or extracorporeal membrane oxygenation >/= 5 days

You may not qualify if…

• Primary or secondary sclerosing cholangitis diagnosed before current ICU admission

Where it is running

• Medical University Graz — Graz, Austria (enrolling)

Full record on ClinicalTrials.gov

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