Study of Arginine and Nitric Oxide in Patients With Diabetes

Completed · Not applicable · Has a placebo group

Conditions studied: Ketosis Prone Diabetes

In brief

This study will test the effect of citrulline versus placebo supplementation in ketosis-prone diabetes (KPD) patients on arginine and nitric oxide production and on glucose- and arginine-stimulated insulin secretion and arterial flow-mediated dilation.

Key facts

Study ID

NCT03566524

Run by

Baylor College of Medicine

People needed

10

Starts

2018-07-01

Expected to finish

2022-06-30

Last updated by the study team

2022-07-29

Who can join

Age: 20 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• New onset (defined as receiving a diagnosis within the past 1 year) diagnosis of unprovoked" A-β+ ketosis-prone diabetes
• Aged 20-65 years
• In good health except for diabetes without clinical evidence of micro- or macrovascular complications by history, physical exam and blood chemistries

You may not qualify if…

• Chronic or acute illness
• History of myocardial infarction or coronary artery disease or stroke,
• Renal insufficiency (eGFR <90mL/min/1.73m2; <30 mg albumin / g creatinine in urine)
• Abnormal liver, thyroid, gonadal or adrenal functions
• On medications other than metformin,
• On any hormonal replacement therapy
• Pregnancy

Where it is running

• Baylor St Lukes Medical Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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