Glucose Uptake in Metabolic Tissues After Bariatric Surgery

Stopped early · Not applicable

Conditions studied: Obesity, Insulin Resistance

In brief

The goal of this study is to provide a comprehensive evaluation of whole-body and tissue-specific glucose metabolism after consuming a mixed meal in lean people and people with obesity, before and after 20-35% weight loss induced by Roux-en-Y gastric bypass or sleeve gastrectomy surgery.

Key facts

Study ID

NCT03563885

Run by

Washington University School of Medicine

People needed

1

Starts

2018-10-01

Expected to finish

2019-06-18

Last updated by the study team

2020-01-28

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• BMI 35.0-50.0 kg/m2 for obese group and 18.5-24.9 kg/m2 for the lean group
• Must be scheduled for RYGB or SG surgery

You may not qualify if…

• Previous bariatric surgery
• Unstable weight (>4% change during the last 2 months before entering the study)
• Significant organ system dysfunction (e.g., severe pulmonary or kidney disease)
• Cancer or cancer that has been in remission for <5 years
• Conditions that render subject unable to complete all testing procedures (e.g. metal implants that interfere with imaging procedures; coagulation disorders)
• Use of medications that are known to affect the study outcome measures or increase the risk of study procedures and that cannot be temporarily discontinued for this study
• Pregnant or lactating women
• Persons who are not able to grant voluntary informed consent
• Persons who are unable or unwilling to follow the study protocol or who, for any reason, the research team considers not an appropriate candidate for this study, including non-compliance with screening appointments or study visits

Where it is running

• Center for Human Nutrition — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.