Multi-Center Development of a Novel Diagnostic Test for Alzheimer's Disease

Running, not enrolling · Early Phase 1

Conditions studied: Alzheimer Disease, Mild Cognitive Impairment

In brief

In this multi-center study, the investigators plan to develop a simple blood-based test for early detection of Alzheimer's disease (AD). The test is based on a single injection of Pramlintide, an amylin analogue and FDA-approved drug currently used for treatment of diabetes. The investigative team has provided evidence in humans with full-blown AD and AD-relevant mouse models that a single injection of Pramlintide transiently renders the blood brain barrier (BBB) more permeable to Amyloidbeta (Aß) peptides, allowing their efflux from the brain compartment into the blood. This Aß efflux causes a corresponding transient elevation of blood levels of Aß, the magnitude of which the applicants believe is proportional to the brain amyloid load as determined by AV-45 PET. The measured difference in the level of plasma Aß taken just before and a short time after injection should reveal the magnitude of the transient increase in blood Aß levels. Supportive preliminary data comes from later stage (full-blown) AD patients with more in-depth background studies in Tg2576 and 5X Familial Alzheimer's Disease (FAD) mouse models. If successful for use as an early AD biomarker (i.e., at the Mild Cognitive Impairment (MCI) stage), this could be a game-changer for both early AD diagnostics and clinical trials aimed at identifying and testing the efficacy of drugs useful for treatment of AD at early stages. If Pramlintide is effective in releasing mobile pools of Aß from the brain into the blood, this could also have some therapeutic potential, with the goal of reducing brain amyloid load. Three groups of participants will be studied: 1) amnestic MCI with or without positive AD imaging pathology, 2) probable AD with positive imaging AD pathology, and 3) controls who have normal cognition and do not have memory complaints.

Key facts

Study ID

NCT03560960

Run by

Boston University

People needed

57

Starts

2020-02-04

Expected to finish

2026-11-01

Last updated by the study team

2026-05-28

Who can join

Age: 60 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current research subjects at the BU , Memory Center VA Boston Healthcare, or Indiana University Alzheimer Disease Center
• A consensus diagnosis of probable Alzheimer's Disease (AD), amnestic mild cognitive impairment (MCI), or control
• BMI of 20-35
• Probable AD subjects must be confirmed for positive AD pathology in the central nervous center (CNS0
• Probable AD subjects must have a designated research proxy signed before they became demented.

You may not qualify if…

• Diabetes mellitus
• Gastroparesis
• Use of insulin, pramlintide, other injectable anti-hyperglycemic agents, such as glucagon like peptide-1 (GLP-1), or oral anti-diabetic products
• Unexplained hypoglycemia (glucose ≤ 60 mg/dL) or hyperglycemia (glucose ≥ 126 mg/dL) pre-injection
• History of stroke
• Seizures or use of anti-seizure medications
• History of brain injury and loss of consciousness
• Diagnosed cerebral amyloid angiopathy (CAA)
• Infection within 1 month

Where it is running

• Indiana University Alzheimer Disease Center — Indianapolis, Indiana, United States
• BU Alzheimer Disease Center — Boston, Massachusetts, United States
• Memory Center VA Boston Healthcare — Jamaica Plain, Massachusetts, United States

Full record on ClinicalTrials.gov

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