Tetrahydrocannabinol (THC) and Sleep

Completed · Early Phase 1

Conditions studied: Sleep, THC, Marijuana, Cannabis

In brief

The investigators will test the effects of 10-60mg dronabinol (oral THC) on sleep in non-frequent and frequent cannabis users.

Key facts

Study ID

NCT03560934

Run by

Oregon Health and Science University

People needed

18

Starts

2018-09-01

Expected to finish

2025-12-31

Last updated by the study team

2026-02-05

Who can join

Age: 21 and older, up to 34. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Frequent Cannabis Use (>3x/week for the prior 3 months) or
• No Cannabis Use (Less than 10x ever)

You may not qualify if…

• Sleep Apnea
• Pregnancy
• Diabetes
• Cardiovascular disease
• Chronic Pain
• History of seizures
• Severe Hepatic impairment
• Conditions associated with clinically relevant cognitive impairment
• Symptoms of acute or active illness (e.g., fever and leukocytosis)
• Evidence of psychopathology on the Beck Depression Index II (BDI-II or in a structured clinical interview with a physician
• History of severe psychiatric illnesses (including such as alcoholism, drug dependency including a cannabis use disorder score ≥12 on the Cannabis Use Disorders Identification Test (CUDIT) (28) or >1 withdrawal symptom on the Marijuana Withdrawal Checklist (MWC (29)) , major depression, manic depressive illness, schizophrenic disorders, panic disorder, generalized anxiety disorder, post-traumatic stress disorder, agoraphobia, claustrophobia, paranoid personality disorder, schizoid personality disorder, schizotypal personality disorder, borderline personality disorder, and antisocial personality disorder.)
• History of having been treated with antidepressants, neuroleptic medications, or tranquilizers.
• Volunteers must be drug-free (including caffeine, nicotine, alcohol and herbal medications) for the duration of the screening and study period (with the exception of THC), with no dependence on drugs (e.g. cocaine, opioids, amphetamine, methamphetamine, PCP, benzodiazepines, barbiturates, methadone, MDMA); or alcohol dependency.
• Current Nicotine use ( or history of more than 5 'pack years' of smoking)
• Current use of prescription or over the counter medications
• History of shift work in the last 6 months
• Travel across >2 time zones during the month prior to the study
• Habitual bedtime after 1am or waketime before 5am

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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