A Study Evaluating the Efficacy and Safety of AG-348 in Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)

Completed · Phase 3

Conditions studied: Pyruvate Kinase Deficiency, Anemia, Hemolytic

In brief

Study AG348-C-007 was a multicenter study designed to evaluate the efficacy and safety of treatment with AG-348 in a minimum of 20, with up to 40, participants with pyruvate kinase (PK) deficiency, who were regularly receiving blood transfusions. The study was composed of two parts. During Part 1, Dose Optimization Period, participants started on a dose of 5 mg AG-348 administered twice daily. Over the course of Part 1 each participant's dose of AG-348 was sequentially increased to 20 mg twice a day, followed by 50 mg twice a day depending on their tolerance. During Part 2, Fixed-Dose Period, participants received AG-348 at their optimized dose from Part 1.

Key facts

Study ID

NCT03559699

Run by

Agios Pharmaceuticals, Inc.

People needed

27

Starts

2018-06-26

Expected to finish

2020-11-12

Last updated by the study team

2022-01-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Informed consent;
• Male or female, aged 18 or older;
• Presence of at least 2 mutant alleles in the Pyruvate Kinase Liver and RBC (PKLR) gene, of which at least 1 is a missense mutation;
• History of a minimum of 6 transfusion episodes in the 52-week period prior to date of informed consent;
• Complete records of transfusion history for the 52 weeks prior to the date of informed consent, including all transfusion dates, number of blood units transfused for all the transfusions, and Hb concentrations within 1 week prior to transfusion for at least 80% of the transfusions;
• Have received at least 0.8 mg of oral folic acid daily for at least 21 days prior to the first dose of study drug, to be continued daily during study participation;
• Have adequate organ function;
• Negative serum pregnancy test for women of reproductive potential;
• For women of reproductive potential as well as fertile men and their partners who are women of reproductive potential: be abstinent or agree to use 2 forms of contraception, 1 of which must be considered highly effective, from the time of giving informed consent, during the study, and for 28 days following the last dose of AG-348;
• Willing to comply with all study procedures, in particular the individual transfusion trigger (TT) calculated based on 52 weeks of transfusion history, for the duration of the study.

You may not qualify if…

• Homozygous for the R479H mutation or have 2 non-missense mutations, without the presence of another missense mutation, in the PKLR gene;
• Significant medical condition that confers an unacceptable risk to participate in the study, and/or that could confound the interpretation of the study data;
• History of transfusions occurring on average more frequently than once every 3 weeks during the 52 weeks prior to date of informed consent;
• Splenectomy scheduled during the study treatment period or have undergone splenectomy within 12 months prior to signing informed consent;
• Currently enrolled in another therapeutic clinical trial. Prior participation in the PK Deficiency Natural History Study (NHS) (NCT02053480) or PK Deficiency Registry is permitted;
• Exposure to any investigational drug, device, or procedure within 3 months prior to the first dose of study drug;
• Prior bone marrow or stem cell transplant;
• Currently pregnant or breastfeeding;
• History of major surgery within 6 months of signing informed consent;
• Currently receiving medications that are strong inhibitors of CYP3A4, strong inducers of CYP3A4, strong inhibitors of P-glycoprotein (P-gp), or digoxin (a P-gp sensitive substrate medication) that have not been stopped for a duration of at least 5 days or 5 times their half-lives (whichever is longer) prior to start of study drug;
• Currently receiving hematopoietic stimulating agents (eg, erythropoietins [EPOs], granulocyte colony stimulating factors, thrombopoietins) that have not been stopped for a duration of at least 28 days prior to the first dose of study drug;
• History of allergy to sulfonamides if characterized by acute hemolytic anemia, drug induced liver injury, anaphylaxis, rash of erythema multiforme type or Stevens-Johnson syndrome, cholestatic hepatitis or other serious clinical manifestations;
• Allergy to AG-348 or its excipients;
• Currently receiving anabolic steroids, including testosterone preparations, within 28 days prior to the first dose of study drug.

Where it is running

• UCSF Benioff Children's Hospital — Oakland, California, United States
• Emory University — Atlanta, Georgia, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Seattle Cancer Care Alliance — Seattle, Washington, United States
• Toronto General Hospital, University Health Network — Toronto, Canada
• University of Copenhagen, Herlev Hospital — Herlev, Denmark
• Hopital Universitaire Henri Mondor — Créteil, France
• Hôpital de la Timone — Marseille, France
• St James's Hospital Department of Haematology — Dublin, Ireland
• Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico — Milan, Italy
• AORN Cardarelli — Naples, Italy
• Ospedale Galliera — Naples, Italy
• AOU Policlinico, Università della Campania "Luigi Vanvitelli" — Naples, Italy
• Universitair Medisch Centrum Utrecht — Utrecht, Netherlands
• Department of Paediatrics and Thalassaemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University — Bangkok, Thailand
• Addenbrooke's Hospital — Cambridge, United Kingdom
• Imperial College Healthcare NHS Trust, Hammersmith Hospital — London, United Kingdom
• University College London — London, United Kingdom
• Manchester Royal Infirmary — Manchester, United Kingdom

Full record on ClinicalTrials.gov

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