Impact of Endothelial and Leukocyte Senescence in Circulatory Shock States

Recruiting now

Conditions studied: Shock, Cardiovascular Diseases, Infection

In brief

Circulatory shocks (CS) are life-threatening, acute organ dysfunction. Advances in critical care medicine have decreased early hospital mortality, increasing the number of surviving patients. Regrettably, these survivors are at increased risk of new infections but also of cardiovascular disease. The investigators hypothesize that CS with multi-organ dysfunction is associated with premature senescence of endothelial cells and immune cells and promotes endothelial thrombogenicity and immunosenescence leading to cardiovascular disease and secondary infections. The aim of this work is therefore to evaluate the contribution of endothelial and leucocytes senescence to the occurrence of secondary events (infectious and cardiovascular) in patients with a CS. It will provide a better understanding of the pathogenesis of cardiovascular and immune diseases following a CS, likely to guide new management strategies to prevent their occurrence.

Key facts

Study ID

NCT03559569

Run by

University Hospital, Strasbourg, France

People needed

520

Starts

2019-01-07

Expected to finish

2028-03-01

Last updated by the study team

2025-03-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Circulatory shock
• patient with health care insurance

You may not qualify if…

• Patients' refusal to participate in clinical research
• Pregnant woman
• Breastfeeding woman
• A patient with a protective order

Where it is running

• Hôpitaux Universitaires de Strasbourg - Service de Réanimation médicale du NHC — Strasbourg, France (enrolling)

Full record on ClinicalTrials.gov

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