Determine the Clinical Advantage of IV vs PO Acetaminophen

Completed · Phase 4 · Has a placebo group

Conditions studied: Inguinal Hernia

In brief

There is limited research on the clinical outcome differences between intravenous (IV) acetaminophen versus oral (PO) acetaminophen. With the costs of intravenous acetaminophen sometimes being almost 100 times the cost of PO acetaminophen, it is not only important fiscally but also clinically to differentiate the benefits of IV vs PO acetaminophen. The proposed research study is to determine the clinical advantages of IV vs PO acetaminophen during the post-operative recovery time for ambulatory surgery patients by analyzing differences in time to first opioid delivery, pain scores, and patient satisfaction.

Key facts

Study ID

NCT03558555

Run by

Yan Lai

People needed

103

Starts

2017-12-08

Expected to finish

2018-12-30

Last updated by the study team

2020-02-10

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• ASA scores I-III
• Ambulatory surgery patients
• Ages 18-75
• Surgeries requiring general anesthesia for hernia surgery

You may not qualify if…

• Patients with contraindications to acetaminophen (history of end organ liver dysfunction)
• Known allergy to acetaminophen
• Emergency surgery
• Patients who were not fasted
• Patients who cannot tolerate PO
• Surgery anticipated to last longer than 3 hours or requiring re-dose of acetaminophen
• Pregnancy
• Weight less than 50kg
• Chronic daily narcotic use
• Patients who's anesthetic plan requires regional anesthesia
• Patient refusal to participate or do not have capacity to provide consent.

Where it is running

• Mount Sinai West Hospital — New York, New York, United States

Full record on ClinicalTrials.gov

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