Multi-Center Study of Sensory Stimulation to Improve Brain Function

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Alzheimer Disease, Cognitive Impairment, Mild Cognitive Impairment, Dementia Alzheimers, Dementia, Mild, Dementia, Alzheimer Type, Dementia of Alzheimer Type, Dementia, Cognitive Impairment, Mild, Cognitive Decline

In brief

The Overture Study is a randomized, controlled, single-blind multi-center clinical trial using the GammaSense Stimulation system to study safety, tolerability, and efficacy in people with mild to moderate cognitive impairment.

Key facts

Study ID

NCT03556280

Run by

Cognito Therapeutics, Inc.

People needed

60

Starts

2018-04-24

Expected to finish

2021-09-01

Last updated by the study team

2021-08-24

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• >= 55 Years old
• MMSE 14-26
• Prodromal Alzheimer's Disease (AD), AD or Mild Cognitive Impairment (MCI) due to AD
• Participation of a caregiver

You may not qualify if…

• Profound hearing or visual impairment
• Seizure Disorder
• Use of memantine (Namenda or Namzaric)
• Implantable devices (non-MR compatible)

Where it is running

• Brain Matters Research — Delray Beach, Florida, United States
• Brain Matters Research — Stuart, Florida, United States
• ActivMed Practices & Research, Inc — Methuen, Massachusetts, United States
• Boston Center for Memory — Newton, Massachusetts, United States
• The Cognitive and Research Center of New Jersey — Springfield, New Jersey, United States

Full record on ClinicalTrials.gov

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