Constitution of a Clinico-radiological Database and a Biobank for Patients With Lacunar Infarcts

Recruiting now

Conditions studied: Lacunar Strokes

In brief

The aim of this study is to determine in patients with a recent lacunar strokes (\<15 days), the natural history of cognitive disturbances and disability.

Key facts

Study ID

NCT03552926

Run by

Assistance Publique - Hôpitaux de Paris

People needed

500

Starts

2018-06-06

Expected to finish

2027-08-30

Last updated by the study team

2022-05-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years and above
• History of recent (less than 15 days) neurological deficit related to a small subcortical infarct (evidenced by medical history or physical examination)
• Diagnosis of recent small subcortical infarct on MRI (hyperintensity on diffusion-weighted imaging showing an infarction in the territory of one perforating artery) presumably responsible for the corresponding neurological deficit
• Lesion diameter mess than 20 mm
• Ability to comply with scheduled follow-up and annual neurological evaluation
• Affiliation to the national French health insurance (sécurité sociale)
• Signature of informed consent

You may not qualify if…

• Prior diagnosis of dementia according to DSM IV criteria
• Prior severe disability with Rankin scale ≥ 4
• Serious concomitant systemic disorder that can compromise the follow-up study;
• Leukoencephalopathy of non-vascular origin;
• Severe psychiatric disorder;
• Inability to obtain an informed signed consent from the patient or his/her family;
• Medical contraindication or refusal to undergo cerebral magnetic resonance scanning (MRI).

Where it is running

• Hôpital Lariboisière — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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