The Effect of Oral Antibiotics on Synovial Fluid and Differential for the Diagnosis of Infection
Withdrawn before enrolling · Not applicable
Conditions studied: Infection
In brief
Periprosthetic joint infection following total hip or knee arthroplasty is a rare but potentially devastating complication. Accurate diagnosis of these infections remains one of the most challenging undertakings in orthopaedics. Multiple studies have shown the high diagnostic accuracy of synovial fluid white blood cell count (WBC) and neutrophil percentage (%PMNs) in detecting PJI. This study's goal is to evaluate how antibiotics affect those two important diagnostic measures.
Key facts
- Study ID
- NCT03551847
- Run by
- Rush University Medical Center
- People needed
- 0
- Starts
- 2011-07-01
- Expected to finish
- 2019-11-05
- Last updated by the study team
- 2021-08-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient>18 years old.
- Patient with a prosthetic hip or knee in place.
- Patient with PJI of the hip or knee based on MSIS criteria3(Table 1).
- Patient off of antibiotics for a minimum of two weeks prior to preoperative joint aspiration.
- Patient with a culture-positive preoperative joint aspiration
You may not qualify if…
- Inadequate preoperative or intraoperative synovial fluid sample to perform synovial fluid WBC, %PMN and aerobic/anaerobic cultures.
- Pregnant women.
Where it is running
- Rush University medical Center — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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