Role of Interferon-gamma 1-b (IFN-γ) on Cells of the Innate Immune System: Functional, Biochemical and Gene Expression Studies in Patients With Chronic Granulomatous Disease
Completed
Conditions studied: Chronic Granulomatous Disease
In brief
The overall goal of the study is to investigate the functional, biochemical, and gene expression effects of Interferon-gamma 1-b (IFN-γ) on the neutrophils of patients with Chronic Granulomatous Disease (CGD). The investigators hypothesize that the clinical effects demonstrated in patients with CGD treated with IFN-γ (decreased number and severity of infections) are the result of biochemical processes and upregulation of specific genes, which lead to enhanced functionality of this immune cell population.
Key facts
- Study ID
- NCT03548818
- Run by
- University of Colorado, Denver
- People needed
- 9
- Starts
- 2018-05-16
- Expected to finish
- 2020-07-15
- Last updated by the study team
- 2021-01-22
Who can join
Age: 5 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Current treatment with IFN-γ or intent to treat with this drug
- Acute infections resolved
- Subject is off treatment medications
- Women of childbearing potential must have:
- a negative urine beta-HCG, and
- be willing to practice two forms of effective contraception for the duration of study participation
You may not qualify if…
- Pregnancy,
- Breast-feeding, or
- Unwillingness to use effective contraception
- Recent vaccination (within the last fourteen days)
- Current infection or acute health condition requiring treatment
- Chronic inflammatory complications of CGD including:
- gastric outlet or urinary tract obstruction,
- pleuritis,
- pericarditis,
- inflammatory bowel disease, or
- colitis requiring treatment.
- Un-associated chronic lung, liver, kidney, or cardiac disorders requiring active treatment
Where it is running
- University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States
Full record on ClinicalTrials.gov
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