INSIGHT-AHP: A Study to Characterize the Prevalence of Acute Hepatic Porphyria (AHP) in Patients With Clinical Presentation and History Consistent With AHP

Stopped early

Conditions studied: Acute Hepatic Porphyria, Hepatic Porphyrias, Acute Intermittent Porphyria (AIP), Hereditary Coproporphyria (HCP), Variegate Porphyria (VP), ALA Dehydratase Deficient Porphyria (ADP), Porphyria Acute

In brief

This study will use specific diagnostic tests on a group of patients who are experiencing symptoms typical of acute hepatic porphyria (AHP) to determine how many have the condition, and to potentially help improve the diagnostic process for patients in the future.

Key facts

Study ID

NCT03547297

Run by

Alnylam Pharmaceuticals

People needed

212

Starts

2018-05-29

Expected to finish

2019-01-15

Last updated by the study team

2019-01-25

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥ 16 years of age
• Recurrent and severe episodes of abdominal pain that last for at least 24 hours
• At least 1 episode of severe abdominal pain that required an urgent healthcare visit in the past 12 months
• Other symptoms related to AHP that your doctor will discuss with you
• Willing and able to comply with protocol required assessments and provide written informed consent

You may not qualify if…

• Known diagnosis of AHP
• Alternative explanation for abdominal pain with clinical response to treatment specific for alternative diagnosis

Where it is running

• Clinical Trial Site — Pasadena, California, United States
• Clinical Trial Site — Jacksonville, Florida, United States
• Clinical Trial Site — Margate, Florida, United States
• Clinical Trial Site — Ames, Iowa, United States
• Clinical Trial Site — Las Vegas, Nevada, United States
• Clinical Trial Site — Manhasset, New York, United States
• Clinical Trial Site — Winston-Salem, North Carolina, United States
• Clinical Trial Site — Pittsburgh, Pennsylvania, United States
• Clinical Trial Site — Pottsville, Pennsylvania, United States
• Clinical Trial Site — Knoxville, Tennessee, United States
• Clinical Trial Site — Houston, Texas, United States
• Clinical Trial Site — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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