Rolandic Epilepsy Genomewide Association International Study

Completed

Conditions studied: Rolandic Epilepsy

In brief

We have discovered a small change in the genetic code which increases the risk of the brainwave abnormality that is found in rolandic epilepsy. We now wish to confirm this using a second much larger sample of patients. We will investigate the other genetic changes that cause people with the brainwave abnormality to develop seizures, as well as problems with speech, coordination, attention and learning.

Key facts

Study ID

NCT03547050

Run by

King's College London

People needed

210

Starts

2018-06-01

Expected to finish

2023-06-30

Last updated by the study team

2023-10-06

Who can join

Age: 6 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Rolandic Epilepsy in accordance with the following international criteria:
• Age of first afebrile seizure 3-12 years
• Seizures comprising focal sensorimotor seizures affecting the vocal tract and face, with or without involvement of the arm
• Predominant sleep-related seizures
• EEG interictal centro-temporal spikes with normal background
• Current age 6-25 years

You may not qualify if…

• No history of focal seizure
• Normal EEG or abnormal background features on EEG
• Known structural causes (stroke, tuberous sclerosis, infection, post-infectious or metabolic)
• Primary diagnosis of autism or global learning disability
• Focal central neurological deficit on clinical exam,
• Unable to provide informed consent
• Unable to provide blood sample

Where it is running

• Columbia University Medical Center — New York, New York, United States
• Hasbro Children's Hospital — Providence, Rhode Island, United States
• Seattle Children's Hospital — Seattle, Washington, United States
• Dr. Juan P. Garrahan Children's Hospital — Buenos Aires, Argentina
• Hospital for Sick Kids — Toronto, Ontario, Canada
• Aghia Sophia Children's Hospital of Athens — Athens, Greece
• Sicilian Epilepsy Network — Catania, Italy
• Commissione Genetica Lega Italiana contro l'Epilepssia — Roma, Italy
• Hospital Mutua de Terrassa — Barcelona, Spain
• Cardiff University School of Medicine — Cardiff, United Kingdom
• Guy's and St Thomas' NHS Foundation Trust — London, United Kingdom
• King's College Hospital NHS Foundation Trust — London, United Kingdom
• Swansea University College of Medicine — Swansea, United Kingdom

Full record on ClinicalTrials.gov

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