Fox BioNet Project: LRRK2-002
Completed
Conditions studied: Parkinson Disease
In brief
The overall objective of this study is to determine whether LRRK2 kinase activity and/or mitochondrial DNA (mtDNA) damage could serve as potential biomarkers in PD.
Key facts
- Study ID
- NCT03545425
- Run by
- Michael J. Fox Foundation for Parkinson's Research
- People needed
- 114
- Starts
- 2018-05-16
- Expected to finish
- 2020-04-30
- Last updated by the study team
- 2021-09-08
Who can join
Age: 30 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- LRRK2 Parkinson Disease (PD) Subjects:
- Patients must have confirmed LRRK2 mutation
- Patients must meet the MDS criteria for Parkinson's disease
- Disease duration: any
- Male or female age 30 years or older at time of PD diagnosis.
- Idiopathic PD Subjects:
- Patients must meet the MDS criteria for Parkinson's disease.
- Disease duration: any
- Male or female age 30 years or older at time of PD diagnosis.
- Non-manifesting LRRK2 mutation carriers:
- Patients must have confirmed LRRK2 mutation
- Male or female age 30 years or older at Screening.
- Control (C) Subjects:
- Male or female age 30 years or older at Screening.
You may not qualify if…
- LRRK2 Parkinson Disease (PD) Subjects:
- Inability to provide informed consent
- Participation in a blinded clinical trial of any kind or an unblinded trial of an investigational product that is not currently approved for use in humans.
- Treatment for cancer in the last 5 years.
- Idiopathic PD Subjects:
- Inability to provide informed consent
- Participation in a blinded clinical trial of any kind or an unblinded trial of an investigational product that is not currently approved for use in humans.
- Treatment for cancer in the last 5 years.
- Non-manifesting LRRK2 mutation carriers:
- Inability to provide informed consent
- Participation in a blinded clinical trial of any kind or an unblinded trial of an investigational product that is not currently approved for use in humans.
- Treatment for cancer in the last 5 years.
- Control Subjects:
- Inability to provide informed consent
- Participation in a blinded clinical trial of any kind or an unblinded trial of an investigational product that is not currently approved for use in humans.
- Treatment for cancer in the last 5 years
Where it is running
- Charles E. Schmidt College of Medicine, Florida Atlantic University — Boca Raton, Florida, United States
- Northwestern University — Chicago, Illinois, United States
- Columbia University Medical Center — New York, New York, United States
- Oregon Health and Sciences University — Portland, Oregon, United States
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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