The Effects of Low Dose Atropine on Choroidal Thickness

Completed · Phase 4

Conditions studied: Myopia

In brief

Atropine eye drops are considered to be an effective form of myopia control in human eyes. However, the mechanism by which it exerts it effects are not fully understood. Thickening of the choroid subsequent to atropine administration may play an important role in the mechanisms by which atropine induces myopia control. Literature also notes that choroidal thickness undergoes diurnal variations, which is a variable that will be controlled in this study in order to examine atropine's effects on different baseline choroidal thicknesses. The purpose of the proposed study is to characterize better the influence of atropine on choroid thickness. The study aims are to: 1. Determine the effect of low dose concentration of topical atropine (0.1% and 0.01%) on choroid thickness 2. Determine the effect of topical atropine on choroid thickness in relationship to baseline thickness throughout the day and after one week of daily instillation Hypothesis: Atropine's effect on choroidal thickness will be dependent on the subject's baseline thickness measurements, at a designated time of the day when the choroid is at its thinnest.

Key facts

Study ID

NCT03544827

Run by

State University of New York College of Optometry

People needed

36

Starts

2018-05-21

Expected to finish

2019-02-08

Last updated by the study team

2019-02-15

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged between 18 - 35 years
• Good general and ocular health
• Soft contact lens wearers to cease lens wear for at least 24 hours
• No previous rigid gas permeable lens wear
• Not taking monoamine oxidase inhibitors (MAOIs) and are not pregnant

You may not qualify if…

• History of ocular surgery, including refractive surgery
• Use of ocular medications
• Amblyopia
• Conditions where topical atropine is contraindicated
• Any eye or systemic disease that affect vision or refractive error

Where it is running

• SUNY College of Optometry — New York, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.