Cognitive Impairment, Retinopathy, and Cerebrovascular Lesions in the Elderly

Recruiting now

Conditions studied: Cerebral Small Vessel Diseases, Retinopathy, Cognitive Dysfunction

In brief

The CIRCLE study is a single-center prospective observational study that enrolled individuals with cerebral small vessel disease (SVD), while free of known dementia or stroke (both cerebral infarction and hemorrhage). The patients will receive neuropsychological testing, retinal digital images and multimodal magnetic resonance imaging (MRI). Blood samples will also be collected. Recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy will be evaluated on both baseline and follow-up brain MRIs. The investigators will explore the predictors of preogression of SVD and cognitive deficits.

Key facts

Study ID

NCT03542734

Run by

Second Affiliated Hospital, Zhejiang University, School of Medicine

People needed

1000

Starts

2010-01-01

Expected to finish

2031-06-30

Last updated by the study team

2023-02-06

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult (≥40y; no upper limit)
• Free of known dementia or stroke (both cerebral infarction and hemorrhage)

You may not qualify if…

• Any MRI contraindications
• Serious head injury (resulting to loss of consciousness) or received intracranial surgery
• Suffering from cancer

Where it is running

• The second affiliated hospital of Zhejiang University — Hangzhou, China (enrolling)

Full record on ClinicalTrials.gov

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