Injections of Autologous PRP in Women With Primary Ovarian Insufficiency

Completed · Not applicable

Conditions studied: Primary Ovarian Insufficiency, Premature Menopause

In brief

Premature ovarian failure is a loss of normal function before age 40, leading to infertility and hypoestrogenism. This study will involve only adult women with a diagnosis of POI. Participants will receive injections of autologous PRP in one randomly selected ovary.

Key facts

Study ID

NCT03542708

Run by

Center for Human Reproduction

People needed

34

Starts

2018-07-25

Expected to finish

2024-04-01

Last updated by the study team

2024-07-10

Who can join

Age: 21 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Signed and dated informed consent
• Women 40 years of age and younger with documented primary ovarian insufficiency.
• Normal Karyotype
• FSH > 30
• AMH not detectable
• No evidence of follicles > 4mm
• Must have two ovaries of approximately equal volume.
• No Aspirin or any NSAID (e.g. Motrin) for approximately one week before treatment
• Willingness to undergo further fertility treatment, including IVF if there is evidence of response

You may not qualify if…

• Premature ovarian failure due to a genetic origin, such as Turner's Syndrome or chromosomal abnormality
• Marked thrombocytopenia
• Blood diseases
• Hypofibrinogenemia
• Hemodynamic instability
• Anticoagulant or antiaggregant treatment
• Oncological diseases (specially, skeletal system and blood)
• Sepsis
• Acute and chronic infectious diseases
• Autoimmune diseases, for example, lupus erythematosus, etc.
• Active substance abuse or dependence
• Major Mental health disorder

Where it is running

• Center For Human Reproduction — New York, New York, United States

Full record on ClinicalTrials.gov

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