Effects of Curcumin Supplementation on Gut Barrier Function in Patients With Metabolic Syndrome
Completed · Not applicable
Conditions studied: Obesity, High Blood Pressure, High Cholesterol, Type2 Diabetes, Heart Diseases
In brief
This study will investigate the effects of curcumin on the structure/function of the body by investigating whether targeted improvement of intestinal barrier function by supplementation with oral curcumin will result in attenuation of lipopolysaccharide (LPS) translocation and/or intestinal inflammation.
Key facts
- Study ID
- NCT03542240
- Run by
- Virginia Commonwealth University
- People needed
- 15
- Starts
- 2018-09-19
- Expected to finish
- 2020-11-13
- Last updated by the study team
- 2021-01-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Based on National Institutes of Health (NIH) definition of Metabolic syndrome, the subject must meet at least 3 of the following criteria:
- A. Waist Circumference: Female ≥ 88 cm, Male ≥ 102 cm B. Blood Pressure: ≥ 130/85 mm/Hg and/or treatment with blood pressure lowering medication C. Impaired fasting glucose or HbA1c (fasting glucose ≥ 100 mg/dl or HgA1c ≥ 5.7 D. HDL-C: Females< 50 mg/dl, Males < 40 mg/dl E. Triglycerides ≥ 150 mg/dl
- Willing and able to comply with the study protocol
You may not qualify if…
- Diabetes
- Established cardiovascular disease
- Pre-existing liver disease other than NAFLD
- Chronic kidney disease (Stage 4 and 5)
- Rheumatological disease
- Active malignancy
- Alcohol consumption greater than 7 drinks per week for females and greater than 14 drinks per week for males
- Current use of metformin and/or steroids
- Curcumin supplementation
- Females of child-bearing potential (NOT of child-bearing potential is defined as s/p hysterectomy or post-menopausal.)
- Prisoners/wards of the state and individuals with limited English proficiency
Where it is running
- Virginia Commonwealth University — Richmond, Virginia, United States
Full record on ClinicalTrials.gov
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