Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?

Completed · Phase 4 · Has a placebo group

Conditions studied: Sickle Cell Anemia Crisis

In brief

The purpose of this study is to determine whether IV acetaminophen can decrease the need for subsequent opioid administration in the acute management of sickle cell crisis pain in the pediatric emergency room.

Key facts

Study ID

NCT03541980

Run by

Newark Beth Israel Medical Center

People needed

71

Starts

2018-02-20

Expected to finish

2020-02-20

Last updated by the study team

2021-04-02

Who can join

Age: 4 and older, up to 16. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Any patient age 4-16 years with sickle cell disease who presents the Pediatric ER with acute sickle cell pain crisis with a pain of 6/10 or higher

You may not qualify if…

• Patient with fever (38C or 100.4F)
• Patient less than age 4 years
• Patient greater than age 16 years
• Patient with hypersensitivity/allergy to either morphine, NSAIDs, or acetaminophen
• Patient received acetaminophen within the past 4 hours
• Patient with known liver disease or renal disease
• Patient not requiring IV morphine (pain score 5/10 or less)
• Patient enrolled in the study within the past 72 hours

Where it is running

• Newark Beth Israel — Newark, New York, United States

Full record on ClinicalTrials.gov

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