The Epigenetics of Exercise and Physical Activity in COPD

Status unconfirmed

Conditions studied: Copd

In brief

This study seeks to examine genome-wide DNA methylation patterns associated with physical activity and exercise capacity from peripheral blood collected from participants with chronic obstructive pulmonary disease (COPD) before and after participation in a structured 9-week outpatient pulmonary rehabilitation program.

Key facts

Study ID

NCT03539042

Run by

VA Boston Healthcare System

People needed

50

Starts

2018-03-01

Expected to finish

2021-06-30

Last updated by the study team

2018-05-30

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >40 years
• Diagnosis of COPD (defined as an FEV1/FVC<0.7 or evidence of emphysema on radiologist's read of a chest CT obtained in the course of patient's usual care)
• Referral to and participation in the VA Boston Pulmonary Rehabilitation program

You may not qualify if…

• Active or unstable cardiac disease
• Inability to ambulate > 1 block
• Recent acute exacerbation of COPD (defined as new or increased dose of systemic steroids and/or antibiotics for pulmonary indications)

Where it is running

• VA Boston Healthcare System — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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