Osimertinib With Stereotactic Radiosurgery (SRS) in Brain Metastases From EGFR Positive NSCLC

Completed · Phase 1

Conditions studied: NSCLC, Non-small Cell Lung Cancer

In brief

Investigating potential of controlling brain metastases in patients with EGFR positive NSCLC.

Key facts

Study ID

NCT03535363

Run by

Case Comprehensive Cancer Center

People needed

6

Starts

2018-10-26

Expected to finish

2022-04-01

Last updated by the study team

2024-03-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed pathology of EGFR mutation positive NSCLC with new brain metastases.
• Ability to care for self and ability to walk 50% of waking hours (ECOG Performance Status of 0-2)
• 1-10 brain metastases with intra-cranial brain metastasis must measure 3cm or less in the greatest dimension.
• Hemoglobin ≥9 g/dL, White Blood Count Absolute ≥3.0 x 10\^9/L, Granulocyte count ≥1.5 x 10\^9/L, and platelet count ≥100 x 10\^9/L
• Serum Bilirubin ≤ 1.5 x upper limit of normal (ULN)
• AST and/or ALT ≤ 2 ULN (≤ 5 x ULN when clearly attributable to liver metastases)
• Serum creatinine ≤ 1.5 ULN or calculated creatinine clearance > 60ml/min
• For women of childbearing potential-Negative pregnancy test within one week prior to start of therapy.
• For all sexually active male and female patients of reproductive potential, employ two methods of highly effective and acceptable forms of contraception throughout the study and for 120 days following the final dose of osimertinib.

You may not qualify if…

• Patients with leptomeningeal metastases documented by MRI or cerebrospinal fluid (CSF).
• Significant intratumoral or peritumoral hemorrhage
• Brain metastases within 5 mm of the optic chiasm or optic nerve
• Brainstem metastases
• Gastrointestinal disorders with diarrhea as a major symptom
• Clinically significant or uncontrolled cardiac disease (NYHA functional classification of 3 or 4)
• Pre-existing interstitial lung disease or pneumonitis
• Unable to undergo brain MRI
• HIV or Hepatitis B or C
• Prior treatments must be resolved to an asymptomatic state at time of enrollment
• Medical conditions that could cause safety risks
• Currently receiving investigational cancer therapy.
• Mean QT interval corrected heart rate (QTc)≥470ms calculated from 3 EKGs
• Left Ventricular Ejection Fraction (LVEF) ≤ 50%
• Use of strong CYP3A inhibitors
• Use of strong CYP3A4 inducers
• Use of potent CYP2C8 inhibitors
• Hypersensitivity to osimertinib or any of its ingredients
• corneal ulceration
• pregnant or breast-feeding

Where it is running

• Maimi Cancer Institute - Baptist Health South Florida — Miami, Florida, United States
• Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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