Use of NGS Cell-free Pathogen Test for Identification of Low Risk Fever & Neutropenia in Pediatric Patients

Completed

Conditions studied: Neutropenia, Fever

In brief

Febrile neutropenia is a common complication in pediatric oncology patients. Standard of care requires admission of all patients for intravenous antibiotics until cultures are negative, patients are afebrile and there are signs of bone marrow recovery. This often results in prolonged hospital admissions with significant financial costs, decreased quality of life and potential secondary infections. More recent data suggests it may be possible to identify a "low risk" group that can be discharged prior to signs of bone marrow recovery. At this time, researchers have been unable to identify a model that is safe for early discharge across institutions.

Key facts

Study ID

NCT03530072

Run by

Karius, Inc.

People needed

15

Starts

2018-05-07

Expected to finish

2019-10-31

Last updated by the study team

2023-02-10

Who can join

Age: 1 and older, up to 22. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pediatric oncology patients, aged 1-22, treated at Lucile Packard Children's Hospital (LPCH)

You may not qualify if…

• Relapsed disease
• Acute lymphoblastic leukemia during induction
• Acute myeloid leukemia during any phase of treatment
• Philadelphia-chromosome positive ALL
• Down syndrome
• Patients who have received an allogeneic stem cell transplant.

Where it is running

• Lucille Packard Children's Hopsital — Stanford, California, United States

Full record on ClinicalTrials.gov

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