A Study Comparing Recurrent Use of MSIR, Percocet, and Vicodin at Discharge From the ED

Withdrawn before enrolling · Phase 4

Conditions studied: Pain

In brief

This is a prospective randomized, clinical trial comparing recurrent use of Morphine Sulfate Immediate Release (MSIR), Oxycodone/Acetaminophen (Percocet), and Hydrocodone/Acetaminophen (Vicodin) at discharge from the emergency department for opioid-naive adult patients presenting with moderate-to-severe pain. At discharge, patients will be randomized to receive either 5 mg of Oxycodone/Acetaminophen (Percocet) tablet 4 times a day for 5 days, 5 mg of Hydrocodone/Acetaminophen (Vicodin) tablet 4 times a day for 5 days, or 15 mg Morphine Sulfate Immediate Release (MSIR) tablet 4 times a day for 5 days. At 1 month, 3 months, and 6 months patients' prescription's history will be accessed by using the DoctorFirst Drug Database to determine the recurrent use that will serve as a surrogate marker of likeability and abuse liability of each prescribed opioid.

Key facts

Study ID

NCT03529331

Run by

Antonios Likourezos

People needed

0

Starts

2019-09-01

Expected to finish

2021-12-31

Last updated by the study team

2019-04-23

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ED patient
• 18 and older
• acute to moderate to severe pain
• requires oral opioid medications at ED discharge.

You may not qualify if…

• chronic non-cancer and cancer pain,
• patients with history of substance abuse
• patients with opioid use disorder,
• patients simultaneously taking antidepressants, benzodiazepines and other sedative-hypnotics,
• and allergies to any of the medications.

Where it is running

• Maimonides Medical Center — Brooklyn, New York, United States

Full record on ClinicalTrials.gov

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